for energy & Aging
Nicotinamide adenine dinucleotide (NAD+) is a small molecule that is found in every single one of your cells. It acts as a coenzyme and facilitates many biological processes within the body. This includes the repair of damaged DNA, energy production and metabolism, and various immune functions. Adequate NAD+ levels are important for the optimal functioning of the mitochondria, which are the energy powerhouse of the cell. Optimal NAD+ levels have been demonstrated to be beneficial in preventing and in addressing a variety of different chronic and age-related diseases.
NAD+, the Sirtuin Family of Enzymes, and Your Risk for Chronic Disease
NAD+ helps to regulate a group of enzymes called sirtuins. Sirtuins are dependent on sufficient NAD+ levels to function properly. The enzymes increase antioxidant pathways and therefore play a key role in decreasing and otherwise responding to oxidative stress. They also facilitate the repair of damaged DNA and play critical roles in energy metabolism modulation, cell survival, inflammation modulation, and circadian rhythm regulation.
Sirtuins are also able to enhance insulin sensitivity, and promote a wide range of other health benefits. They have been demonstrated to be beneficial in supporting optimal athletic performance, mental clarity, concentration, and memory. Many studies suggest that sirtuins decrease your risk for age-related diseases and help to promote longevity.
The Effect of Age on NAD+ and Sirtuins
As you grow older, your NAD+ levels naturally decline and this negatively impacts the function and activity of sirtuins. Consequently, as NAD+ levels decline, your risk for age-related diseases like diabetes, high cholesterol, cardiovascular disease, cancer, neurodegenerative disease, non-alcoholic fatty liver disease (NAFLD), and other types of liver disease increases. Declining NAD+ levels may also play a role in increasing risk for chronic fatigue syndrome.
Even after NAD+ levels and sirtuin activity have begun to decline with age, therapeutically increasing NAD+ levels such as through intravenous nutrient therapy, and activating sirtuins as a result, has been demonstrated to be protective against as well as to facilitate improvements in these chronic conditions.
The Best Way to Replenish NAD+ Levels
While there are many NAD+ supplements available on the market today, research has not been able to prove that our NAD+ levels increase when we take these supplements by mouth. This may be because the supplements are not well-absorbed or because they are converted to another molecule in the gastrointestinal tract. Intravenous infusions, on the other hand, are an excellent way to replenish NAD+ levels within the body, to support optimal sirtuin activity, and to treat and/or decrease your risk of being diagnosed with chronic and age-related diseases. Presently, NAD+ delivered intravenously over the course of several sessions is the most effective medically recognized way to increase plasma and tissue levels of NAD+ and reap its health benefits.
articles and references
Anti-Aging Pod Cast - What is NAD